Biocatalytic site- and enantioselective oxidative dearomatization of phenols.

ABSTRACT: The biocatalytic transformations used by chemists are often restricted to simple functional-group interconversions. In contrast, nature has developed complexity-generating biocatalytic reactions within natural product pathways. These sophisticated catalysts are rarely employed by chemists, because the substrate scope, selectivity and robustness of these catalysts are unknown. Our strategy to bridge the gap between the biosynthesis and synthetic chemistry communities leverages the diversity of catalysts available within natural product pathways. Here we show that, starting from a suite of biosynthetic enzymes, catalysts with complementary substrate scope as well as selectivity can be identified. This strategy has been applied to the oxidative dearomatization of phenols, a chemical transform

SUBMITTER: Baker Dockrey SA 

PROVIDER: S-EPMC6503525 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature