Association of Variants in PINX1 and TREM2 With Late-Onset Alzheimer Disease.

ABSTRACT:

Importance

Genetic causes of late-onset Alzheimer disease (LOAD) are not completely explained by known genetic loci. Whole-exome and whole-genome sequencing can improve the understanding of the causes of LOAD and provide initial steps required to identify potential therapeutic targets.

Objective

To identify the genetic loci for LOAD across different ethnic groups.

Design, setting, and participants

This multicenter cohort study was designed to analyze whole-exome sequencing data from a multiethnic cohort using a transethnic gene-kernel association test meta-analysis, adjusted for sex, age, and principal components, to identify genetic variants associated with LOAD. A meta-analysis was conducted on the results of 2 independent studies of whole-exome and whole-genome seq

SUBMITTER: Tosto G 

PROVIDER: S-EPMC6503572 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature