Five-year survival outcomes for patients with advanced melanoma treated with pembrolizumab in KEYNOTE-001.

ABSTRACT:

Background

Pembrolizumab demonstrated robust antitumor activity and safety in the phase Ib KEYNOTE-001 study (NCT01295827) of advanced melanoma. Five-year outcomes in all patients and treatment-naive patients are reported herein. Patients whose disease progressed following initial response and who received a second course of pembrolizumab were also analyzed.

Patients and methods

Patients aged ≥18 years with previously treated or treatment-naive advanced/metastatic melanoma received pembrolizumab 2 mg/kg every 3 weeks, 10 mg/kg every 3 weeks, or 10 mg/kg every 2 weeks until disease progression, intolerable toxicity, or patient/investigator decision to withdraw. Kaplan-Meier estimates of overall survival (OS) and progression-free survival (PFS) were calculated. Objective respo

SUBMITTER: Hamid O 

PROVIDER: S-EPMC6503622 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature