Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis.

ABSTRACT: Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious exposures across the lifespan. DNA methylation (DNAm) has been proposed as a biomarker of biological aging that conserves memory of endogenous and exogenous stress during life.We examined the association of education level, as an indicator of SEP, and lifestyle-related variables with four biomarkers of age-dependent DNAm dysregulation: the total number of stochastic epigenetic mutations (SEMs) and three epigenetic clocks (Horvath, Hannum and Levine), in 18 cohorts spanning 12 countries.The four biological aging biomarkers were associated with education and different sets of risk factors indepen

SUBMITTER: Fiorito G 

PROVIDER: S-EPMC6503871 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature