Patterns of cross-resistance and collateral sensitivity between clinical antibiotics and natural antimicrobials.

ABSTRACT: Bacteria interact with a multitude of other organisms, many of which produce antimicrobials. Selection for resistance to these antimicrobials has the potential to result in resistance to clinical antibiotics when active compounds target the same bacterial pathways. The possibility of such cross-resistance between natural antimicrobials and antibiotics has to our knowledge received very little attention. The antimicrobial activity of extracts from seaweeds, known to be prolific producers of antimicrobials, is here tested against Staphylococcus aureus isolates with varied clinical antibiotic resistance profiles. An overall effect consistent with cross-resistance is demonstrated, with multidrug-resistant S. aureus strains being on average more resistant to seaweed extracts. This

SUBMITTER: Colclough A 

PROVIDER: S-EPMC6503891 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature