Combination of protein coding and noncoding gene expression as a robust prognostic classifier in stage I lung adenocarcinoma.

ABSTRACT: Prognostic tests for patients with early-stage lung cancer may provide needed guidance on postoperative surveillance and therapeutic decisions. We used a novel strategy to develop and validate a prognostic classifier for early-stage lung cancer. Specifically, we focused on 42 genes with roles in lung cancer or cancer prognosis. Expression of these biologically relevant genes and their association with relapse-free survival (RFS) were evaluated using microarray data from 148 patients with stage I lung adenocarcinoma. Seven genes associated with RFS were further examined by quantitative reverse transcription PCR in 291 lung adenocarcinoma tissues from Japan, the United States, and Norway. Only BRCA1, HIF1A, DLC1, and XPO1 were each significantly associated with prognosis in the Japan and US/

SUBMITTER: Akagi I 

PROVIDER: S-EPMC6503978 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature