Role of beta-2-microglobulin as a biomarker in very preterm and extremely preterm infants with CNS inflammation.

ABSTRACT:

Background

Premature infants are at risk for severe sepsis and meningitis, both infections associated with high mortality and morbidity. Cerebro-spinal fluid (CSF) culture is the gold standard method for meningitis diagnosis, but interpretation of biochemical parameters of CSF is essential at the moment of the analysis in order to start the appropriate treatment. The main objective of this study was to determine whether levels of CSF beta-2-microglobulin (B2M) were elevated in preterm infants with CNS infections or other inflammatory processes, and to establish if there were differences in B2M concentrations amongst various inflammatory settings (sepsis, meningitis, and progressive post-hemorrhagic ventricular dilatation (PHVD)).

Methods

This is a retrospective study of all

SUBMITTER: Batista Munoz A 

PROVIDER: S-EPMC6504082 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature