Analyzing the symmetrical arrangement of structural repeats in proteins with CE-Symm.

ABSTRACT: Many proteins fold into highly regular and repetitive three dimensional structures. The analysis of structural patterns and repeated elements is fundamental to understand protein function and evolution. We present recent improvements to the CE-Symm tool for systematically detecting and analyzing the internal symmetry and structural repeats in proteins. In addition to the accurate detection of internal symmetry, the tool is now capable of i) reporting the type of symmetry, ii) identifying the smallest repeating unit, iii) describing the arrangement of repeats with transformation operations and symmetry axes, and iv) comparing the similarity of all the internal repeats at the residue level. CE-Symm 2.0 helps the user investigate proteins with a robust and intuitive sequence-to-structure anal

SUBMITTER: Bliven SE 

PROVIDER: S-EPMC6504099 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature