Genome-wide sexually antagonistic variants reveal long-standing constraints on sexual dimorphism in fruit flies.

ABSTRACT: The evolution of sexual dimorphism is constrained by a shared genome, leading to 'sexual antagonism', in which different alleles at given loci are favoured by selection in males and females. Despite its wide taxonomic incidence, we know little about the identity, genomic location, and evolutionary dynamics of antagonistic genetic variants. To address these deficits, we use sex-specific fitness data from 202 fully sequenced hemiclonal Drosophila melanogaster fly lines to perform a genome-wide association study (GWAS) of sexual antagonism. We identify approximately 230 chromosomal clusters of candidate antagonistic single nucleotide polymorphisms (SNPs). In contradiction to classic theory, we find no clear evidence that the X chromosome is a hot spot for sexually antagonistic variation. Char

SUBMITTER: Ruzicka F 

PROVIDER: S-EPMC6504117 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature