Leveraging heterogeneity for neural computation with fading memory in layer 2/3 cortical microcircuits.

ABSTRACT: Complexity and heterogeneity are intrinsic to neurobiological systems, manifest in every process, at every scale, and are inextricably linked to the systems' emergent collective behaviours and function. However, the majority of studies addressing the dynamics and computational properties of biologically inspired cortical microcircuits tend to assume (often for the sake of analytical tractability) a great degree of homogeneity in both neuronal and synaptic/connectivity parameters. While simplification and reductionism are necessary to understand the brain's functional principles, disregarding the existence of the multiple heterogeneities in the cortical composition, which may be at the core of its computational proficiency, will inevitably fail to account for important phenomena and limit t

SUBMITTER: Duarte R 

PROVIDER: S-EPMC6504118 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature