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CD4⁺ resident memory T cells dominate immunosurveillance and orchestrate local recall responses.

ABSTRACT: This study examines the extent to which memory CD4⁺ T cells share immunosurveillance strategies with CD8⁺ resident memory T cells (T_RM). After acute viral infection, memory CD4⁺ T cells predominantly used residence to survey nonlymphoid tissues, albeit not as stringently as observed for CD8⁺ T cells. In contrast, memory CD4⁺ T cells were more likely to be resident within lymphoid organs than CD8⁺ T cells. Migration properties of memory-phenotype CD4⁺ T cells in non-SPF parabionts were similar, generalizing these results to diverse infections and conditions. CD4⁺ and CD8⁺ T_RM shared overlapping transcriptional signatures and location-specific features, such as granzyme B

SUBMITTER: Beura LK

PROVIDER: S-EPMC6504216 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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CD4⁺ resident memory T cells dominate immunosurveillance and orchestrate local recall responses.

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CD4+ resident memory T cells dominate immunosurveillance and orchestrate local recall responses.

OmicsDI is part of the ELIXIR infrastructure

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CD4⁺ resident memory T cells dominate immunosurveillance and orchestrate local recall responses.