A bipartite iron-dependent transcriptional regulation of the tryptophan salvage pathway in Chlamydia trachomatis.

ABSTRACT: During infection, pathogens are starved of essential nutrients such as iron and tryptophan by host immune effectors. Without conserved global stress response regulators, how the obligate intracellular bacterium Chlamydia trachomatis arrives at a physiologically similar 'persistent' state in response to starvation of either nutrient remains unclear. Here, we report on the iron-dependent regulation of the trpRBA tryptophan salvage pathway in C. trachomatis. Iron starvation specifically induces trpBA expression from a novel promoter element within an intergenic region flanked by trpR and trpB. YtgR, the only known iron-dependent regulator in Chlamydia, can bind to the trpRBA intergenic region upstream of the alternative trpBA prom

SUBMITTER: Pokorzynski ND 

PROVIDER: S-EPMC6504234 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature