Enhancing Osteosarcoma Killing and CT Imaging Using Ultrahigh Drug Loading and NIR-Responsive Bismuth Sulfide@Mesoporous Silica Nanoparticles.

ABSTRACT: Despite its 5-year event-free survival rate increasing to 60-65% due to surgery and chemotherapy, osteosarcoma (OS) remains one of the most threatening malignant human tumors, especially in young patients. Therefore, a new approach that combines early diagnosis with efficient tumor eradication and bioimaging is urgently needed. Here, a new type of mesoporous silica-coated bismuth sulfide nanoparticles (Bi₂ S₃ @MSN NPs) is developed. The well distributed mesoporous pores and large surface areas hold great promise for drug protection and encapsulation (doxorubicin (DOX), 99.85%). Moreover, the high photothermal efficiency of Bi₂ S₃ @MSNs (36.62%) offers great possibility for cancer synergistic treatment and highly near-infrared-triggered drug relea

SUBMITTER: Lu Y 

PROVIDER: S-EPMC6504251 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature