Deletion of Enigma Homologue from the Z-disc slows tension development kinetics in mouse myocardium.

ABSTRACT: Enigma Homologue (ENH) is a component of the Z-disc, a structure that anchors actin filaments in the contractile unit of muscle, the sarcomere. Cardiac-specific ablation of ENH protein expression causes contractile dysfunction that ultimately culminates in dilated cardiomyopathy. However, whether ENH is involved in the regulation of myocardial contractility is unknown. To determine if ENH is required for the mechanical activity of cardiac muscle, we analyze muscle mechanics of isolated trabeculae from the hearts of ENH ^+/+ and ENH ^-/- mice. We detected no differences in steady-state mechanical properties but show that when muscle fibers are allowed to relax and then are restretched, the rate at which tension redevelops is depressed in ENH ^-/-

SUBMITTER: Gregorich ZR 

PROVIDER: S-EPMC6504290 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature