Trauma Induces Emergency Hematopoiesis through IL-1/MyD88-Dependent Production of G-CSF.

ABSTRACT: The inflammatory response to infection or injury dramatically increases the hematopoietic demand on the bone marrow to replace effector leukocytes consumed in the inflammatory response. In the setting of infection, pathogen-associated molecular patterns induce emergency hematopoiesis, activating hematopoietic stem and progenitor cells to proliferate and produce progeny for accelerated myelopoiesis. Sterile tissue injury due to trauma also increases leukocyte demand; however, the effect of sterile tissue injury on hematopoiesis is not well described. We find that tissue injury alone induces emergency hematopoiesis in mice subjected to polytrauma. This process is driven by IL-1/MyD88-dependent production of G-CSF. G-CSF induces the expansion of hematopoietic progenitors, including hematopoie

SUBMITTER: Fuchs A 

PROVIDER: S-EPMC6504560 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature