Bach2 Negatively Regulates T Follicular Helper Cell Differentiation and Is Critical for CD4⁺ T Cell Memory.

ABSTRACT: T follicular helper (Tfh) cells are essential for germinal center B cell responses. The molecular mechanism underlying the initial Tfh cell differentiation, however, is still incompletely understood. In this study, we show that in vivo, despite enhanced non-Tfh cell effector functions, the deletion of transcription factor Bach2 results in preferential Tfh cell differentiation. Mechanistically, the deletion of Bach2 leads to the induction of CXCR5 expression even before the upregulation of Ascl2. Subsequently, we have identified a novel regulatory element in the murine CXCR5 locus that negatively regulates CXCR5 promoter activities in a Bach2-dependent manner. Bach2 deficiency eventually results in a collapsed CD4⁺ T cell response with severely impaired CD4⁺ T cell mem

SUBMITTER: Geng J 

PROVIDER: S-EPMC6504585 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature