Genome-Wide Interaction and Pathway Association Studies for Body Mass Index.

ABSTRACT: Objective: We investigated gene interactions (epistasis) for body mass index (BMI) in a European-American adult female cohort via genome-wide interaction analyses (GWIA) and pathway association analyses. Methods: Genome-wide pairwise interaction analyses were carried out for BMI in 493 extremely obese cases (BMI > 35 kg/m²) and 537 never-overweight controls (BMI < 25 kg/m²). To further validate the results, specific SNPs were selected based on the GWIA results for haplotype-based association studies. Pathway-based association analyses were performed using a modified Gene Set Enrichment Algorithm (GSEA) (GenGen program) to further explore BMI-related pathways using our genome wide association study (GWAS) data set, GIANT, ENGAGE, and DIAGRAM Consortia.

SUBMITTER: Jiao H 

PROVIDER: S-EPMC6504780 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature