An in-silico approach for discovery of microRNA-TF regulation of DISC1 interactome mediating neuronal migration.

ABSTRACT: Neuronal migration constitutes an important step in corticogenesis; dysregulation of the molecular mechanisms mediating this crucial step in neurodevelopment may result in various neuropsychiatric disorders. By curating experimental data from published literature, we identified eight functional modules involving Disrupted-in-schizophrenia 1 (DISC1) and its interacting proteins that regulate neuronal migration. We then identified miRNAs and transcription factors (TFs) that form functional feedback loops and regulate gene expression of the DISC1 interactome. Using this curated data, we conducted in-silico modeling of the DISC1 interactome involved in neuronal migration and identified the proteins that either facilitate or inhibit neuronal migrational processes. We also studied the effect of

SUBMITTER: John JP 

PROVIDER: S-EPMC6504871 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature