Facilitated Diffusion Mechanisms in DNA Base Excision Repair and Transcriptional Activation.

ABSTRACT: Preservation of the coding potential of the genome and highly regulated gene expression over the life span of a human are two fundamental requirements of life. These processes require the action of repair enzymes or transcription factors that efficiently recognize specific sites of DNA damage or transcriptional regulation within a restricted time frame of the cell cycle or metabolism. A failure of these systems to act results in accumulated mutations, metabolic dysfunction, and disease. Despite the multifactorial complexity of cellular DNA repair and transcriptional regulation, both processes share a fundamental physical requirement that the proteins must rapidly diffuse to their specific DNA-binding sites that are embedded within the context of a vastly greater number of nonspecific DNA-b

SUBMITTER: Esadze A 

PROVIDER: S-EPMC6504930 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature