Ontology highlight
ABSTRACT:
SUBMITTER: Souren NY
PROVIDER: S-EPMC6504952 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Nature communications 20190507 1
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system with a modest concordance rate in monozygotic twins, which strongly argues for involvement of epigenetic factors. We observe highly similar peripheral blood mononuclear cell-based methylomes in 45 MS-discordant monozygotic twins. Nevertheless, we identify seven MS-associated differentially methylated positions (DMPs) of which we validate two, including a region in the TMEM232 promoter and ZBTB16 enhan ...[more]