Human β-defensin 1 in follicular fluid and semen: impact on fertility.

ABSTRACT: PURPOSE:β-defensins are antimicrobial peptides expressed at mucosal level of male and female genito-urinary tract, where they exert protective functions against infections, possibly preserving human health and fertility. In our study, we investigated the possible involvement of β-defensins in female and male infertility in Italian infertile couples (i) evaluating the presence of human β-defensin 1 (hBD-1) in follicular fluid (FF) and its correlation with in vitro fertilization (IVF) outcomes; (ii) investigating the relationship between hBD-1 levels in semen and IVF outcomes (comprising correlation with sperm parameters); and (iii) exploring the effect of hBD-1 peptide on spermatozoa motility in vitro. METHODS:A perspective observational analytic pilot study was conducted. hBD-1 concentrati

SUBMITTER: Zupin L 

PROVIDER: S-EPMC6504998 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature