Whole Genome Sequencing and Progress Toward Full Inbreeding of the Mouse Collaborative Cross Population.

ABSTRACT: Two key features of recombinant inbred panels are well-characterized genomes and reproducibility. Here we report on the sequenced genomes of six additional Collaborative Cross (CC) strains and on inbreeding progress of 72 CC strains. We have previously reported on the sequences of 69 CC strains that were publicly available, bringing the total of CC strains with whole genome sequence up to 75. The sequencing of these six CC strains updates the efforts toward inbreeding undertaken by the UNC Systems Genetics Core. The timing reflects our competing mandates to release to the public as many CC strains as possible while achieving an acceptable level of inbreeding. The new six strains have a higher than average founder contribution from non-domesticus strains than the previously released

SUBMITTER: Shorter JR 

PROVIDER: S-EPMC6505143 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature