Exploration of carbohydrate binding behavior and anti-proliferative activities of Arisaema tortuosum lectin.

ABSTRACT:

Background

Lectins have come a long way from being identified as proteins that agglutinate cells to promising therapeutic agents in modern medicine. Through their specific binding property, they have proven to be anti-cancer, anti-insect, anti-viral agents without affecting the non-target cells. The Arisaema tortuosum lectin (ATL) is a known anti-insect and anti-cancer candidate, also has interesting physical properties. In the present work, its carbohydrate binding behavior is investigated in detail, along with its anti-proliferative property.

Results

The microcalorimetry of ATL with a complex glycoprotein asialofetuin demonstrated trivalency contributed by multiple binding sites and enthalpically driven spontaneous association. The complex sugar specificity of ATL towards

SUBMITTER: Thakur K 

PROVIDER: S-EPMC6505227 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature