Effect of BRCA mutational status on survival outcome in advanced-stage high-grade serous ovarian cancer.

ABSTRACT:

Objective

To evaluate impact of germline BRCA mutational status on prognosis in patients with advanced ovarian cancer.

Methods

A total of 128 patients diagnosed with FIGO stage III-IV high-grade serous ovarian cancer (HGSOC) between 2008 and 2017 and underwent BRCA1/2 gene testing at the time of or within two years from cancer diagnosis were included in this study. We compared patients' clinicopathological characteristics and survival outcomes after primary treatment according to germline BRCA mutational status. Treatment-related factors that might affect patients' survival outcome were also investigated.

Results

Germline BRCA1/2 mutations were observed in 51 women (39.8%). There were no differences in age and serum CA-125 levels at the time of HGSOC diagnosis, use of

SUBMITTER: Kim SI 

PROVIDER: S-EPMC6505247 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature