Green tea extract catechin improves cardiac function in pediatric cardiomyopathy patients with diastolic dysfunction.

ABSTRACT:

Background

Our previous studies have demonstrated that Ca²⁺ desensitizing catechin could correct diastolic dysfunction in experimental animals with restrictive cardiomyopathy. In this study, it is aimed to assess the effects of green tea extract catechin on cardiac function and other clinical features in pediatric patients with cardiomyopathies.

Methods

Twelve pediatric cardiomyopathy patients with diastolic dysfunction were enrolled for the study. Echocardiography, ECG, and laboratory tests were performed before and after the catechin administration for 12?months. Comparison has been made in these patients before and after the treatment with catechin. Next Generation Sequencing was conducted to find out the potential causative gene variants in all patients.

Results

A significant decrease of isovolumetric relaxation time (115?±?46 vs 100?±?42?ms, P?=?0.047 at 6?months; 115?±?46 vs 94?±?30?ms, P?=?0.033 at 12?months), an increase of left ventricle end diastolic volume (40?±?28 vs 53?±?28?ml, P?=?0.028 at 6?months; 40?±?28 vs 48?±?33?ml, P?=?0.011 at 12?months) and stroke volume (25?±?16 vs 32?±?17?ml, P?=?0.022 at 6?months; 25?±?16 vs 30?±?17?ml, P?=?0.021 at 12?months) were observed with echocardiography in these patients 6-month after the treatment with catechin. Ejection fraction, left ventricular wall thickness, biatrial dimension remained unchanged. No significant side effects were observed in the patients tested.

Conclusions

This study indicates that Ca²⁺ desensitizing green tea extract catechin, is helpful in correcting the impaired relaxation in pediatric cardiomyopathy patients with diastolic dysfunction.

SUBMITTER: Quan J 

PROVIDER: S-EPMC6505250 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature