Green tea extract catechin improves cardiac function in pediatric cardiomyopathy patients with diastolic dysfunction.

ABSTRACT:

Background

Our previous studies have demonstrated that Ca²⁺ desensitizing catechin could correct diastolic dysfunction in experimental animals with restrictive cardiomyopathy. In this study, it is aimed to assess the effects of green tea extract catechin on cardiac function and other clinical features in pediatric patients with cardiomyopathies.

Methods

Twelve pediatric cardiomyopathy patients with diastolic dysfunction were enrolled for the study. Echocardiography, ECG, and laboratory tests were performed before and after the catechin administration for 12 months. Comparison has been made in these patients before and after the treatment with catechin. Next Generation Sequencing was conducted to find out the potential causative gene variants in all patients.

Re

SUBMITTER: Quan J 

PROVIDER: S-EPMC6505250 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature