Casp8 hypomethylation and neural tube defects in association with polycyclic aromatic hydrocarbon exposure.

ABSTRACT:

Background

Epidemiological studies have found that prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with increased risk for neural tube defects (NTDs). Aberrant DNA methylation, excessive apoptosis, and oxidative stress have been implied as the mechanism underlying the association between PAH exposure and NTDs, respectively. However, the role of DNA methylation aberration of apoptotic initiator CASP8 (caspase-8, apoptosis-related cysteine peptidase) in the formation of NTDs in association with PAH exposure is not known. By combining a case-control study and mouse model, we aimed to explore the full spectrum of the links from PAH exposure, oxidative stress, CASP8 methylation change, caspase-8 activation, apoptosis, to NTD formation.

Results

Hypomethy

SUBMITTER: Huang Y 

PROVIDER: S-EPMC6505285 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature