Ontology highlight
ABSTRACT:
SUBMITTER: Indrieri A
PROVIDER: S-EPMC6505685 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
EMBO molecular medicine 20190501 5
Mitochondrial diseases (MDs) are a heterogeneous group of devastating and often fatal disorders due to defective oxidative phosphorylation. Despite the recent advances in mitochondrial medicine, effective therapies are still not available for these conditions. Here, we demonstrate that the microRNAs miR-181a and miR-181b (miR-181a/b) regulate key genes involved in mitochondrial biogenesis and function and that downregulation of these miRNAs enhances mitochondrial turnover in the retina through t ...[more]