Chronic stress induces cell type-selective transcriptomic and electrophysiological changes in the bed nucleus of the stria terminalis.

ABSTRACT: Distinct regions and cell types in the anterolateral group of the bed nucleus of the stria terminalis (BNST_ALG) act to modulate anxiety in opposing ways. A history of chronic stress increases anxiety-like behavior with lasting electrophysiological effects on the BNST_ALG. However, the opposing circuits within the BNST_ALG suggest that stress may have differential effects on the individual cell types that comprise these circuits to shift the balance to favor anxiogenesis. Yet, the effects of stress are generally examined by treating all neurons within a particular region of the BNST as a homogenoeus population. We used patch-clamp electrophysiology and single-cell quantitative reverse transcriptase PCR (scRT-PCR) to determine how chronic shock stress (CSS) aff

SUBMITTER: Daniel SE 

PROVIDER: S-EPMC6505688 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature