Ontology highlight
ABSTRACT:
SUBMITTER: Geha P
PROVIDER: S-EPMC6505710 | biostudies-literature | 2018 Jan-Jul
REPOSITORIES: biostudies-literature
Geha Paul P Schulman Betsy R BR Dib-Hajj Sulayman D SD Waxman Stephen G SG
Neurobiology of pain (Cambridge, Mass.) 20180131
Inherited erythromelalgia (IEM) is a chronic pain disorder caused by gain-of-function mutations of peripheral sodium channel Nav1.7, in which warmth triggers severe pain. Little is known about the brain representation of pain in IEM. Here we study two subjects with the IEM Nav1.7-S241T mutation using functional brain imaging (fMRI). Subjects were scanned during each of five visits. During each scan, pain was first triggered using a warming boot and subjects rated their thermal-heat pain. Next, t ...[more]