Mammographic breast density and its association with urinary estrogens and the fecal microbiota in postmenopausal women.

ABSTRACT:

Background

Breast density, as estimated by mammography, is a strong risk factor for breast cancer in pre- and postmenopausal women, but the determinants of breast density have not yet been established. The aim of this study was to assess if urinary estrogens or gut microbiota alterations are associated with mammographic density in postmenopausal women.

Methods

Among 54 cancer-free, postmenopausal controls in the Breast and Colon Health study, we classified low- versus high-density women with Breast Imaging Reporting and Data System (BI-RADS, 5th edition) mammographic screening data, then assessed associations with urinary estrogens and estrogen metabolites (determined by liquid chromatography/tandem mass spectrometry), and fecal microbiota alpha and beta diversity (using Ill

SUBMITTER: Jones GS 

PROVIDER: S-EPMC6505928 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature