Differences in plasma levels of long chain and very long chain ceramides between African Americans and whites: An observational study.

ABSTRACT:

Background

Population-wide reductions in cardiovascular disease (CVD) have not been equally shared in the African American community due to a higher burden of CVD risk factors such as metabolic disorders and obesity. Differential concentrations of sphingolipids such as ceramide, sphingosine, and sphingosine 1-phosphate (S1P) has been associated with the development of CVD, metabolic disorders (MetD), and obesity. Whether African Americans have disparate expression levels of sphingolipids that explain higher burdens of CVD remains unknown.

Methods

A cross sectional analysis of plasma concentrations of ceramides, sphingosine, and S1P were measured from 8 whites and 7 African Americans without metabolic disorders and 7 whites and 8 African Americans with metabolic disorders usi

SUBMITTER: Buie JNJ 

PROVIDER: S-EPMC6505935 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature