Distinct roles for MDA5 and TLR3 in the acute response to inhaled double-stranded RNA.

ABSTRACT: The airway epithelial barrier is critical for preventing pathogen invasion and translocation of inhaled particles into the lung. Epithelial cells also serve an important sentinel role after infection and release various pro-inflammatory mediators that recruit and activate immune cells. Airway epithelial barrier disruption has been implicated in a growing number of respiratory diseases including viral infections. It is thought that when a pathogen breaks the barrier and gains access to the host tissue, pro-inflammatory mediators increase, which further disrupts the barrier and initiates a vicious cycle of leak. However, it is difficult to study airway barrier integrity in vivo, and little is known about relationship between epithelial barrier function and airway inflammation. Current assays

SUBMITTER: Veazey JM 

PROVIDER: S-EPMC6505938 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature