A pilot study of visceral fat and its association with adipokines, stool calprotectin and symptoms in patients with diverticulosis.

ABSTRACT:

Background

Complications of diverticular disease are increasingly common, possibly linked to increasing obesity. Visceral fat could contribute to the development of symptomatic diverticular disease through its pro-inflammatory effects.

Objective

The study had 2 aims. A) to develop a semi-automated algorithm to measure abdominal adipose tissue from 2-echo magnetic resonance imaging (MRI) data; B) to use this to determine if visceral fat was associated with bowel symptoms and inflammatory markers in patients with symptomatic and asymptomatic diverticular disease.

Design

An observational study measuring visceral fat using MRI together with serum adiponectin, leptin, stool calprotectin and patient-reported somatisation and bowel habit.

Setting

Medical and imaging r

SUBMITTER: Murray KA 

PROVIDER: S-EPMC6505945 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature