Dataset Information

Screening for coeliac disease in children and adults living in a slum of Dhaka, Bangladesh.

ABSTRACT:

Background and objective

Serological screening with a confirmation through biopsy has improved the understanding of coeliac disease (CD) epidemiology worldwide. Prevalence of CD in Bangladesh is not yet explored and therefore, we aimed to assess the seroprevalence of CD in slum-dwelling malnourished children and adults in Dhaka.

Methods

Serum samples were collected from three different cohorts: stunted (length-for-age Z-scores (LAZ) <-2) and at risk of stunting children (LAZ <-1 to -2) and malnourished adults (body mass index <18.5 kg/m²). Samples from all the participants were assessed for anti-tissue transglutaminase antibody (tTG-IgA) and total serum IgA by ELISA. Positive tTG-IgA and randomly selected low IgA values were reconfirmed using anti-tTG-IgG and gliadin IgG ELISA. CD was diagnosed when second screening tests were found positive and the participants were further investigated by small bowel biopsy.

Results

A total of 818 participants (240 stunted, 272 at risk of stunting children and 306 malnourished adults) were enrolled in the study. Overall, anti-tTG-IgA was positive in 5/818 (0.6%; 95% CI 0.25% to 1.46%). Of the five positive cases, anti-tTG-IgG and gliadin IgG were found positive in only one participant. Duodenal biopsy of positive participant revealed characteristic lesions of CD. Randomly selected low IgA values were found negative in tTG-IgG and gliadin IgG for all the participants. No participant was found total IgA deficient.

Conclusion

The incidence of coeliac autoimmunity is low in malnourished slum dwellers regardless of age in Bangladesh. It is important to investigate the nationwide prevalence to reveal the definite picture.

SUBMITTER: Gazi MA

PROVIDER: S-EPMC6506126 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Screening for coeliac disease in children and adults living in a slum of Dhaka, Bangladesh.

Gazi Md Amran MA Das Subhasish S Mahfuz Mustafa M Hasan Md Mehedi MM Hossain Md Shabab MS Fahim Shah Mohammad SM Alam Md Ashraful MA Noor Zannatun Z Gilchrist Carol A CA Petri William A WA Rahman M Masudur MM Mazumder Ramendra Nath RN Haque Rashidul R Sarker Shafiqul Alam SA Ahmed Tahmeed T

BMJ open gastroenterology 20190420 1

<h4>Background and objective</h4>Serological screening with a confirmation through biopsy has improved the understanding of coeliac disease (CD) epidemiology worldwide. Prevalence of CD in Bangladesh is not yet explored and therefore, we aimed to assess the seroprevalence of CD in slum-dwelling malnourished children and adults in Dhaka.<h4>Methods</h4>Serum samples were collected from three different cohorts: stunted (length-for-age Z-scores (LAZ) <-2) and at risk of stunting children (LAZ <-1 t ...[more]

PMID: 31139429

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Dataset Information

Screening for coeliac disease in children and adults living in a slum of Dhaka, Bangladesh.

Background and objective

Methods

Results

Conclusion

Publications

Screening for coeliac disease in children and adults living in a slum of Dhaka, Bangladesh.

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