Significance of bronchiolocentric fibrosis in patients with histopathological usual interstitial pneumonia.

ABSTRACT:

Aims

To evaluate the clinical significance of bronchiolocentric fibrosis (BCF) in patients with a histopathological pattern of usual interstitial pneumonia (UIP).

Methods and results

Two hundred and fifty-two patients with pathological UIP pattern were identified. Two hundred and fifteen of these patients (215 of 252) had the multidisciplinary diagnosis of idiopathic pulmonary fibrosis (IPF). Prospectively defined clinical, radiological and pathological features (including BCF) were recorded, and peripheral blood MUC5B genotype and telomere length were measured. BCF was observed in 38% (96 of 252) of all patients and 33% (72 of 215) of IPF patients; its presence was associated with a non-IPF diagnosis on multivariate analysis (odds ratio = 3.71, 95% confidence interval = 1.6

SUBMITTER: Tanizawa K 

PROVIDER: S-EPMC6506377 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature