The Plasticity of Molecular Interactions Governs Bacterial Microcompartment Shell Assembly.

ABSTRACT: Bacterial microcompartments (BMCs) are composed of an enzymatic core encapsulated by a selectively permeable protein shell that enhances catalytic efficiency. Many pathogenic bacteria derive competitive advantages from their BMC-based catabolism, implicating BMCs as drug targets. BMC shells are of interest for bioengineering due to their diverse and selective permeability properties and because they self-assemble. A complete understanding of shell composition and organization is a prerequisite for biotechnological applications. Here, we report the cryoelectron microscopy structure of a BMC shell at 3.0-Å resolution, using an image-processing strategy that allowed us to determine the previously uncharacterized structural details of the interactions formed by the BMC-T^S and BMC-T<

SUBMITTER: Greber BJ 

PROVIDER: S-EPMC6506404 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature