Genomic analyses across six cancer types identify basal-like breast cancer as a unique molecular entity.

ABSTRACT: To improve our understanding of the biological relationships among different types of cancer, we have characterized variation in gene expression patterns in a set of 1,707 samples representing 6 human cancer types (breast, ovarian, brain, colorectal, lung adenocarcinoma and squamous cell lung cancer). In the unified dataset, breast tumors of the Basal-like subtype were found to represent a unique molecular entity as any other cancer type, including the rest of breast tumors, while showing striking similarities with squamous cell lung cancers. Moreover, gene signatures tracking various cancer- and stromal-related biological processes such as proliferation, hypoxia and immune activation were found expressed similarly in different proportions of tumors across the various cancer types. These d

SUBMITTER: Prat A 

PROVIDER: S-EPMC6506566 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature