Heart and lung doses are independent predictors of overall survival in esophageal cancer after chemoradiotherapy.

ABSTRACT:

Purpose

To analyze associations between heart and lung dose and overall survival (OS) in patients with esophageal cancer who received concurrent chemo-radiotherapy (CCRT) with or without surgery.

Patients and methods

Patients received intensity-modulated radiation therapy (median dose 50.4 Gy) from 2004 through 2016. Cutoff points for continuous variables were calculated using the method of Contal and O'Quigley. Kaplan-Meier method with log-rank tests was used to calculate survival. OS was analyzed with both univariate and multivariable Cox models.

Results

In all, 560 patients were analyzed; median follow-up time was 29.3 months, and 5-year OS rate was 41.7%. Heart V30 >45% and mean lung dose (MLD) >10 Gy were found to be independently associated with worse survival a

SUBMITTER: Xu C 

PROVIDER: S-EPMC6506607 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature