Predicting conversion from mild cognitive impairment to Alzheimer's disease using brain ¹H-MRS and volumetric changes: A two- year retrospective follow-up study.

ABSTRACT: This study investigated the ability of magnetic resonance spectroscopy (¹H-MRS) of posterior cingulate cortex (PCC) and brain volumetry to predict the progression from mild cognitive impairment (MCI) to Alzheimer's Disease (AD) on the basis of clinical classification at 2 years follow-up. Thirty-eight MCI patients, eighteen healthy older adults and twenty-three AD patients were included in this study. All participants underwent a brain-MR protocol (1.5 T GE scanner) including high-resolution T1-weighted volumetric sequence (isotropic 1mm³). Voxel-wise differences in brain volumetry were evaluated using FreeSurfer software and all volumes were normalized by the total intracranial volume (TIV). Careful localization of ¹H-MRS volume of PCC was performed and da

SUBMITTER: Mitolo M 

PROVIDER: S-EPMC6506639 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature