NMDAR-Mediated Ca²⁺ Increase Shows Robust Information Transfer in Dendritic Spines.

ABSTRACT: A dendritic spine is a small structure on the dendrites of a neuron that processes input timing information from other neurons. Tens of thousands of spines are present on a neuron. Why are spines so small and many? We addressed this issue by using the stochastic simulation model of N-methyl-D-aspartate receptor (NMDAR)-mediated Ca²⁺ increase. NMDAR-mediated Ca²⁺ increase codes the input timing information between prespiking and postspiking. We examined how much the input timing information is encoded by Ca²⁺ increase against presynaptic fluctuation. We found that the input timing information encoded in the cell volume (10³μm³) largely decreases against the presynaptic fluctuation, whereas that in the spine volume (10^-1μm

SUBMITTER: Tottori T 

PROVIDER: S-EPMC6506640 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature