Brief Report: Pulmonary Tuberculosis Is Associated With Persistent Systemic Inflammation and Decreased HIV-1 Reservoir Markers in Coinfected Ugandans.

ABSTRACT:

Background

Mycobacterium tuberculosis (TB) infection induces systemic inflammation that could impact HIV-1 persistence.

Setting

HIV-1-seropositive individuals either with or without pulmonary TB disease were recruited in Kampala, Uganda.

Methods

Plasma cytokines, HIV-1 DNA, and cell-associated (ca)-RNA were compared among those coinfected with TB (cases) to those without TB (controls). TB-coinfected cases and controls were compared at presentation (n = 15 and n = 16, respectively) and at around 6 months after HIV-1 treatment initiation among those who had achieved virologic suppression (n = 6 and n = 8, respectively). At follow-up, the TB-coinfected cases had also finished TB treatment.

Results

Before treatment, the TB-coinfected cases as compared to the contro

SUBMITTER: Olson A 

PROVIDER: S-EPMC6506856 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature