Low frequency of mismatch repair deficiency in gallbladder cancer.

ABSTRACT:

Background

DNA mismatch repair (MMR) deficiency is a major pathway of genomic instability in cancer. It leads to the accumulation of numerous mutations predominantly at microsatellite sequences, a phenotype known as microsatellite instability (MSI). MSI tumors have a distinct clinical behavior and commonly respond well to immune checkpoint blockade, irrespective of their origin. Data about the prevalence of MSI among gallbladder cancer (GBC) have been conflicting. We here analyzed a well-characterized cohort of 69 Western-world GBCs.

Methods

We analyzed the mononucleotide MSI marker panel consisting of BAT25, BAT26, and CAT25 to determine the prevalence of MMR deficiency-induced MSI.

Results

MSI was detected in 1/69 (1.4%) of analyzed GBCs. The detected MSI GBC had a

SUBMITTER: Goeppert B 

PROVIDER: S-EPMC6506936 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature