Resolving repeat families with long reads.

ABSTRACT:

Background

Draft quality genomes for a multitude of organisms have become common due to the advancement of genome assemblers using long-read technologies with high error rates. Although current assemblies are substantially more contiguous than assemblies based on short reads, complete chromosomal assemblies are still challenging. Interspersed repeat families with multiple copy versions dominate the contig and scaffold ends of current long-read assemblies for complex genomes. These repeat families generally remain unresolved, as existing algorithmic solutions either do not scale to large copy numbers or can not handle the current high read error rates.

Results

We propose novel repeat resolution methods for large interspersed repeat families and assess their accuracy on simula

SUBMITTER: Bongartz P 

PROVIDER: S-EPMC6506941 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature