Within-sample co-methylation patterns in normal tissues.

ABSTRACT:

Background

DNA methylation is an epigenetic event that may regulate gene expression. Because of this regulation role, aberrant DNA methylation is often associated with many diseases. Within-sample DNA co-methylation is the similarity of methylation in nearby cytosine sites of a chromosome. It is important to study co-methylation patterns. However, it is not well studied yet, and it is unclear to us what co-methylation patterns normal DNA samples have. Are the co-methylation patterns of the same tissue across several samples different? Are the co-methylation patterns of various tissues of the same sample different? To answer these questions, we conduct analyses using two sets of data: 3-sample-1-tissue (3S1T) and 1-sample-8-tissue (1S8T).

Results

To study the co-methylation p

SUBMITTER: Sun L 

PROVIDER: S-EPMC6506960 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature