NRAS and KRAS polymorphisms are not associated with hepatoblastoma susceptibility in Chinese children.

ABSTRACT:

Background

Hepatoblastoma is the most common hepatic malignancy in children, accounting for approximately 80% of all childhood liver tumors. KRAS and NRAS, members of the RAS gene family, are closely linked to tumorigenesis, and are frequently mutated in a variety of malignancies. They may thus play critical roles in tumorigenesis. However, there are few studies on the association between the RAS gene polymorphisms and risk of hepatoblastoma.

Methods

We investigated whether the polymorphisms at these genes are associated with hepatoblastoma susceptibility in a hospital-based study of 213 affected Chinese children and 958 cancer-free controls. Genotypes were determined by TaqMan assay, and association with hepatoblastoma risk was assessed based on

SUBMITTER: Yang T 

PROVIDER: S-EPMC6507155 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature