Role of Thioredoxin 1 in Impaired Renal Sodium Excretion of hD ₅ R ^F173L Transgenic Mice.

ABSTRACT: Background Dopamine D₅ receptor (D₅R) plays an important role in the maintenance of blood pressure by regulating renal sodium transport. Our previous study found that human D₅R mutant F173L transgenic ( hD ₅ R ^F173L-TG) mice are hypertensive. In the present study, we aimed to investigate the mechanisms causing this renal D₅R dysfunction in hD ₅ R ^F173L-TG mice. Methods and Results Compared with wild-type D₅R-TG ( hD ₅ R ^WT-TG) mice, hD ₅ R ^F173L-TG mice have higher blood pressure, lower basal urine flow and sodium excretion, and impaired agonist-mediated natriuresis and diuresis. Enhanced reactive oxygen species production in hD ₅ R

SUBMITTER: Wang S 

PROVIDER: S-EPMC6507211 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature