SpliceV: analysis and publication quality printing of linear and circular RNA splicing, expression and regulation.

ABSTRACT:

Background

In eukaryotes, most genes code for multiple transcript isoforms that are generated through the complex and tightly regulated process of RNA splicing. Despite arising from identical precursor transcripts, alternatively spliced RNAs can have dramatically different functions. Transcriptome complexity is elevated further by the production of circular RNAs (circRNAs), another class of mature RNA that results from the splicing of a downstream splice donor to an upstream splice acceptor. While there has been a rapid expansion of circRNA catalogs in the last few years through the utilization of next generation sequencing approaches, our understanding of the mechanisms and regulation of circular RNA biogenesis, the impact that circRNA generation has on parental transcript process

SUBMITTER: Ungerleider N 

PROVIDER: S-EPMC6507234 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature