Duration of Exposure to Antipseudomonal β-Lactam Antibiotics in the Critically Ill and Development of New Resistance.

ABSTRACT:

Study objective

Minimizing the duration of broad-spectrum antimicrobial exposure in the critically ill is a commonly used strategy aimed at preventing resistance. Our objective was to correlate the duration of exposure to antipseudomonal β-lactam antibiotics with the development of new resistance in critically ill patients.

Design

Single-center, retrospective cohort study.

Setting

A large, academic, tertiary care hospital.

Patients

A total of 7118 adults with a discharge diagnosis of severe sepsis or septic shock who received at least one dose of cefepime, meropenem, or piperacillin-tazobactam during their hospitalization between 2010 and 2015.

Measurements and main results

Cohort entry was defined as the first day of any antipseudomonal β-lactam initiat

SUBMITTER: Teshome BF 

PROVIDER: S-EPMC6507412 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature