Increased expression of FAK isoforms as potential cancer biomarkers in ovarian cancer.

ABSTRACT: Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that is expressed in most human cell types (example: Epithelial cells, fibroblasts and endothelial), it serves a key role in the control of cell survival, proliferation and motility. The abnormal expression of FAK has been associated with poor prognosis in cancer, including ovarian cancer. However, although FAK isoforms with specific molecular and functional properties have been characterized, there are a limited number of published studies that examine FAK isoforms in ovarian cancer. The aim of the present study was to analyze the expression level of FAK and its isoforms in ovarian cancer. The expression of FAK kinase and focal adhesion targeting (FAT) domains was determined with immunohistochemistry in healthy ovary, and serou

SUBMITTER: Nolasco-Quiroga M 

PROVIDER: S-EPMC6507456 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature