A97 HLA-DQA1-HLA-DRB1 POLYMORPHISM IS A MAJOR PREDICTOR OF AZATHIOPRINE-INDUCED PANCREATITIS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE

ABSTRACT: Abstract

Background

Azathioprine (AZA)-induced pancreatitis is an unpredictable and dose-independent adverse event affecting 2–7% of patients with inflammatory bowel disease (IBD) patients treated with AZA. There are no tools in clinical practice to identify at-risk individuals; however, a genome wide association study (GWAS) identified a strong association between the Class II HLA gene region polymorphism (rs2647087) and AZA-induced pancreatitis.

Aims

To independently confirm the findings of the GWAS in an IBD cohort, to evaluate its utility in clinical practice and to offer a novel AZA treatment algorithm for IBD based on pharmacogenomic principles.

Methods

A retrospective cohort study evaluated 373 AZA-exposed IBD patients from a tertiary care academic centre

SUBMITTER: Wilson A 

PROVIDER: S-EPMC6508404 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature